Moderate alcohol consumption is not sinful in Scripture — Jesus turned water into wine (John 2), Paul recommends wine for Timothy's stomach (1 Timothy 5:23), and Psalm 104 lists wine as a gift from God. Drunkenness is clearly sinful (Ephesians 5:18, Galatians 5:21). The Christian position: drinking is a matter of liberty; drunkenness is sin; wisdom includes knowing your own weaknesses and respecting others' consciences (Romans 14). 62/100 Mixed — liberty within clear limits.
The Bible does not prohibit alcohol. This needs to be stated plainly because many Christians have been taught otherwise. Jesus turned water into wine at Cana — and John 2:10 makes clear this was good wine served after the inferior wine was gone, not grape juice. The Greek word oinos means fermented wine. The Psalms list wine as a gift from God that "gladdens the heart of man" (Psalm 104:15). Paul tells Timothy "use a little wine because of your stomach and your frequent illnesses" (1 Timothy 5:23). The Last Supper included wine. The biblical case for total abstinence from alcohol cannot be made from these texts.
What the Bible does clearly prohibit is drunkenness. Ephesians 5:18 — "Do not get drunk on wine, which leads to debauchery. Instead, be filled with the Spirit." Galatians 5:21 lists drunkenness among the works of the flesh. Proverbs 20:1 — "Wine is a mocker and beer a brawler; whoever is led astray by them is not wise." 1 Peter 4:3 mentions "debauchery, lust, drunkenness, orgies, carousing" as the behavior of the past life. The line Scripture draws is between drinking and being mastered by drink.
Paul's framework in Romans 14-15 applies directly here: some Christians believe they can drink alcohol freely; others, out of conscience or background, abstain. Both positions are valid within Christian liberty. The stronger obligation falls on those who drink: do not cause a weaker brother to stumble, do not drink in contexts where it would harm your witness, and do not drink if you have any tendency toward addiction.
Practical wisdom adds considerations Scripture doesn't explicitly address: is there a history of alcoholism in your family? Does your culture or community context mean your drinking would cause significant offense? Do you have the self-discipline to maintain "moderate"? These prudential questions affect how Christian liberty should be exercised even though they don't change the underlying biblical principle. See also GotQuestions' thorough treatment of alcohol and the Gospel Coalition's framework. See our Is It a Sin? hub and our guide on Is Cussing a Sin?